Research Technician- IBC
Ontario Institute for Cancer Research
Toronto, ON
About us: The OICR is a top-ranking translational cancer research institute located in the Discovery District of downtown Toronto, one of the top three biotechnology hubs in North America and an exceptionally collaborative environment. As part of international cancer research teams, the ICGC (International Cancer Genome Consortium) and TCGA (The Cancer Genome Atlas), we have early access to large and diverse cancer datasets that will become the standard reference set for cancer genomics studies in the coming years. These datasets provide exciting challenges for interpretation, and many opportunities to make new discoveries and to develop innovative computational tools. In particular, we are leading several aspects of the ICGC Pan-Cancer Analysis Working Group (PCAWG), a collaboration of hundreds of experts to analyse whole-genome sequencing (WGS) data across more than 2,800 donors and 50 types of cancer. The recently launched next-generation project ICGCmed will advance precision treatment strategies by linking cancer genomes of >200,000 individuals to high-quality clinical information. Our analyses are performed on cutting-edge IT infrastructure including a multi-petabyte storage system and a >8,000-core compute farm.

About the position: We seek a talented and highly motivated Research Technician to contribute to the development of a world-class bioinformatics platform in cancer genomics. The research questions you will be addressing include: Which genome mutations are important in cancer development and how do they function mechanistically? How are biological pathways and molecular interaction networks altered by mutations, gene regulation, epigenetic modifications and DNA rearrangements? Which genes are promising targets for future drugs, and how can we repurpose existing drugs to treat cancer? How do we build computational models, bioinformatics software and novel visualisations to integrate complex multi-dimensional datasets and discover new knowledge?

As a successful candidate, you will have extensive interest in large-data problems, excellent quantitative analysis skills and in-depth knowledge of cancer genomics. You will analyse diverse -omics datasets to explore the basic biology of cancer and to drive discovery of molecular biomarkers and personalised therapies. You will work closely with the team and the Principal Investigator on cancer genomics projects in collaborations with basic, translational, and clinical researchers at the OICR, in the excellent research community of Toronto and internationally. Your tasks will include:

Integrative analysis of multi-dimensional cancer genomics datasets using statistical and machine learning approaches;
Pre-processing, normalization, and quality control of next-generation sequencing (WGS) and other –omics data;
Development of innovative computational methods and open-source bioinformatics software;
Visualization and interpretation of –omics data with pathway and network information.

Qualifications:
Undergraduate degree in bioinformatics, computational biology, genomics, or computer sciences required
Minimum 2 year of academic or professional experience in bioinformatics;
Strong scientific publication record in peer-reviewed journals on bioinformatics and/or cancer research;
Strong understanding and interest in molecular biology, genomics, and cancer;
Strong knowledge of basic statistics; machine learning skills are a definite plus;
Familiarity with the Linux or MacOSX environment, shell scripting and system tools; experience with high performance computing is an asset;
Minimum 2 years of experience with programming and data analysis in R, Python, Perl, Matlab or similar;
Minimum 2 years of experience with bioinformatics resources, databases, tools and common standard formats;
Minimum 2 years of experience in analysing next-generation sequencing and/or microarray data;
Ability to work independently as well as part of a fast-paced and collaborative team;
Excellent verbal and written communication skills in English.
OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

For more information about OICR, please visit the website at www.oicr.on.ca.

CLOSING DATE: Until Filled

HOW TO APPLY:
OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Training, Colleges and Universities.
The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted. Candidates will be expected to provide their current employer as a reference.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .pdf or.doc file.

Group Benefits Coverage

Sick Days Ten (10) paid days per year

SunLife Group Benefits

Effective Date of Coverage:
The waiting period for your group benefits plan is three (3) months continuous employment.
Premiums are 100% paid by the Institute

Long Term Disability
Premiums are 100% paid by the Institute
Graded Schedule. Maximum is $7,500

Life Coverage
Premiums are 100% paid by the Institute
Two (2) times Annual Basic Earnings up to a maximum of $500,000

Dependent Life
Premiums are 100% paid by the Institute
$5,000 for your spouse
$2,500 per dependent child

Optional Life, Spousal Optional Life, Child Optional Life Insurance
Premiums are 100% paid by the employee
Please refer to your benefit booklet for details on this optional benefit.

Accidental Death & Dismemberment
Premiums are 100% paid by the Institute
Two (2) times Annual Basic Earnings up to a maximum of $500,000

Extended Health Care Coverage
Deductible None

Monthly Premium Monthly premiums are 100% paid by the Institute

Dependent Coverage Covered until age 21 or 25 for full-time students

Prescription Drugs 80% reimbursement
Mandatory Generic Substitution
Prior Authorization (PA) program applies to a limited number of drugs
Fertility Drugs: $2,400 per lifetime maximum
Dispensing Fee Nil

Vision Care 100% reimbursement
$300 every 12 month period for a person less than age 18;
24 month period for any other person. Includes eyeglasses, contact lenses or laser eye corrective surgery
Eye exam - $50 over 2 benefit years

Health Care Practitioners 80% reimbursement
$500 per practitioner per benefit year

Private Nursing 80% reimbursement
$25,000 during any 3 consecutive benefit years

Hearing Care 80% reimbursement
$500 in any 5 benefit year periods

Orthopedic Shoes 80% reimbursement

Extended Health Care Coverage Coverage

Orthotics 80% reimbursement
$350 per benefit year

Out-of-Province Coverage
(Emergency Services) 100% reimbursement
$1,000,000 lifetime maximum
Limited to 60 days trip duration
Hospital within Home Province 100% reimbursement
Semi private room accommodation

Dental Care Coverage
Deductible None

Monthly Premium Monthly premiums are 100% paid by the Institute

Recall Every 5 months

Basic & Minor Restorative 80% reimbursement
Diagnostic / Preventative, Restorative,
Periodontic and Endodontic Services

  • Maximum Coverage
Basic & Minor Restorative
  • Combined maximum of $3,000 per year for all Basic, Minor & Major Restorative
Major Restorative
Crowns, bridges and dentures
50% reimbursement
  • Maximum Coverage
Crowns, bridges and dentures *Combined maximum of $3,000 per year for all Basic, Minor & Major Restorative
TMJ Treatment
(Temporomandibular Joint)
50% reimbursement
$1,000 lifetime maximum

Orthodontics
For adults and children No coverage
Dental Fee Guide
Current Fee Guide for general practitioners

Pension Plan Coverage

Healthcare of Ontario Pension Plan
(HOOPP)
Effective date of coverage: immediate

Employee contributes 6.9% of earnings up to the year’s maximum pensionable earnings (YMPE); and 9.2% of earnings above the YMPE

The YMPE for 2016 is $54,900

Vacation Coverage

Vacation Entitlement
3 weeks (15 days) of paid vacation per year