Alpha-9 Oncology is a clinical-stage biotechnology company developing radiopharmaceuticals for solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. With a strong cash position, raised from leading healthcare investors, Alpha-9 is poised to dramatically expand its team and accelerate its pipeline.
Radiopharmaceuticals, which enable internal delivery of radiation directly to tumor sites, are emerging as an exciting new class of cancer drugs. The field has evolved dramatically in the last few years, attributable to scientific advances and recent product launches. Radiopharmaceuticals are unique in that the same molecule can be used for imaging or therapeutic purposes, allowing doctors to visualize the molecule in patients prior to administration of therapy. The drug development cycle is also much shorter and capital efficient than traditional modalities.
Alpha-9 is seeking a Scientist or Senior Scientist to join our Biology group within our growing organization. The ideal candidate will be team oriented and have excellent knowledge and skills in Cancer/Molecular/Cell Biology, Biochemistry, and or Pharmacology, with a proven experience in in vitro assay development for drug design. Industry experience is required and experience with radiopharmaceutical development is a plus.
- Lead, manage and execute experiments to validate pipeline targets.
- Contribute to the in vitro expertise across pipeline targets
- Design, validate and execute preclinical experiments to demonstrate in vitro activities as well as define mechanism of action of drug candidates.
- Contribute to strategic plans and assays development.
- Expertise in cell culture and in vitro assays to validate targets, screen drug candidates and determine MoA
- Experience with target expression validation (e.g. flow cytometry, ELISA, western blot), andmolecular biology techniques (e.g., qPCR, cloning)
- Interpret and analyze data, prepare, and review study reports, communicate project progress to internal team members and external collaborators.
- Supervise and mentor junior staffs including Associate Scientists
- Assist with lab management tasks such as lab safety advisory, lab inspections and inventories.
- Perform other related duties within the Biology group as needed.
- A PhD in Cancer, Cell or Molecular Biology, Biochemistry, and/or Pharmacology with 2-5+ years of relevant post-doctoral training or industrial experience and a proven track record of scientific excellence and creativity
- Expertise in the development, optimization and execution of assays to establish MoA, binding affinity, selectivity and potency.
- Experience in radiopharmaceutical discovery preferred, but not required.
- Excellent observational, organizational, data management, and documentation skills
- A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment
- Full extended health and dental benefits
- Competitive Salary, Bonus, and Equity
- Commuter Reimbursement
- Group Registered Retirement Savings Plan with 5% employer
- 20 vacation days
- 17 Holidays
- 5 Sick Days
- Long Term Disability
- Life Insurance
- Technology allowance
- Impactful rewarding work
