The Ottoy & Goubran labs at the Sunnybrook Research Institute (SRI), University of Toronto, are seeking a motivated postdoctoral fellow to lead a fully-funded, innovative project at the intersection of Alzheimer’s disease, cerebrovascular disease, and neuroinflammation. You will leverage cutting-edge biomarkers and neuroimaging techniques, including 7T magnetic resonance imaging (MRI), in a dynamic, collegial environment. The main project will focus on employing structural and functional MRI, both at high- and ultra-high-resolution, to study immune-vascular and neuronal dysfunction in Alzheimer’s disease. We will leverage existing large dementia cohorts, as well as a novel cohort to be acquired at SRI. We closely collaborate with a diverse and multidisciplinary team of researchers, including computer scientists, physicists, neurologists, radiologists, and psychologists. We encourage new approaches and ideas, as well as independent projects that align with current studies that involve immune-vascular contributions to dementia.
SRI is the research arm of Sunnybrook Health Sciences Centre (SHSC), a teaching hospital fully affiliated with the University of Toronto. It is a world-renowned research institute known for developing innovative diagnostic and therapeutic imaging technologies. SRI employs over 300 scientists and clinician-scientists, along with more than 1,300 research staff. Working with scientists are more than 600 highly skilled biomedical and research personnel, as well as over 450 postdoctoral fellows and other trainees. SRI possesses state-of-the-art imaging facilities and computational resources, including one 1.5T (GE) and three 3T (GE, Philips, Siemens) research-dedicated MRI systems, a research MRI-PET system (Siemens), a system for MRI-guided focused ultrasound brain treatments, a fully electronically steered phased array system for MRI-guided focused ultrasound for extracranial treatments, a combined X-ray / MRI suite dedicated to research on image-guided interventions, a research CT scanner, a 7T small-bore MRI system, a vertical 7T NMR system, a GE Spinlab polarizer for 13C MRI research, a wide range of ultrasound machines, and a local HPC system. A new 7T human MRI system has recently been installed (the first in Toronto) and will be used in our projects.
Main responsibilities:
- Lead study design, data acquisition, and analyses for a novel project on early-stage fluid and imaging biomarkers for Alzheimer’s disease & cerebral amyloid angiopathy at 3T and 7T MRI. (lay summary here)
- Develop neuroimaging pipelines and computational tools to analyze data from various dementia cohorts, including those from our international collaborators.
- Write scientific manuscripts and fellowship applications. You will develop key skills for academic independence, including grant writing, supervision of students/staff, and presenting at international conferences.
- Collaborate on various other projects focused on neurodegenerative disorders in the labs.
Required Qualifications/Special Skills:
- PhD obtained within the last 5 years or a graduating PhD candidate in computer science, biomedical engineering, biophysics, neuroscience, or a related discipline
- Experience with neuroimaging (MRI and/or PET)
- Strong understanding of Alzheimer’s disease and/or cerebral small vessel disease pathophysiology
- Proficiency with programming languages (Python/R/MATLAB, Bash) and imaging software (e.g., Freesurfer, FSL, MRtrix, fMRIPrep).
- Strong research record, including multiple first-author papers and presentations
- Excellent verbal and written communication skills in English
- Proven ability to work independently as well as collaboratively
This is a fully funded position. Stipend levels are in line with experience and CIHR stipend levels (65,000-75,000 CAD annually), including health and dental benefits. A 2-year minimum commitment is required.
In accordance with Canadian Employment and Immigration guidelines, applicants must be eligible to work in Canada. In accordance with Canadian immigration requirements, this advertisement is directed initially to Canadian citizens and permanent residents, however, everyone is encouraged to apply.
- University of Toronto
- Sunnybrook Research Institute
- Dr. Ottoy’s research profile and spotlight
- Dr. Goubran’s website of the Artificial Intelligence and COmputational NeuroSciences (AICONS) lab
- Dr. Goubran’s Department of Medical Biophysics Profile
- Temerty Faculty of Medicine
- Black Centre for Brain Resilience & Recovery
To apply for this position, please follow the link:
Upload a (1) cover letter (max 1/2 page), (2) Curriculum Vitae, and (3) the contact info of three potential references.
Deadline for application: Until the position is filled. Applications will be reviewed on a rolling basis. Only those candidates selected for an interview will be contacted.
